This study and Louisa Edwards were supported by a British Heart Foundation Junior Research Fellowship (FS/03/128). We thank Adrian Reynolds, Victoria Keighly, and Lin Clarke from the Department of Neurophysiology at University Hospital Birmingham for performing the somatosensory evoked potential measurements.
Effects of essential hypertension on short latency human somatosensory-evoked potentials
Version of Record online: 16 DEC 2009
Copyright © 2009 Society for Psychophysiological Research
Volume 47, Issue 2, pages 323–331, March 2010
How to Cite
Edwards, L., Ring, C., Mcintyre, D., Martin, U. and Winer, J. B. (2010), Effects of essential hypertension on short latency human somatosensory-evoked potentials. Psychophysiology, 47: 323–331. doi: 10.1111/j.1469-8986.2009.00939.x
- Issue online: 8 FEB 2010
- Version of Record online: 16 DEC 2009
- (Received August 13, 2008; Accepted May 17, 2009)
- Arterial hypertension;
- Essential hypertension;
- Median nerve;
- Somatosensory evoked potentials
Reduced perception of somatosensory stimulation in patients with essential hypertension may be due to deficits in the ascending somatosensory pathway. Function in the ascending somatosensory pathway was assessed by measuring N9, N13, and N20 somatosensory-evoked potentials in 14 unmedicated essential hypertensives and 22 normotensives. N9 amplitudes were smaller and N13 amplitudes marginally smaller in hypertensives than normotensives. N9 amplitudes were inversely associated with blood pressure. N20 amplitudes and N9, N13, and N20 latencies did not differ between groups. In addition, plexus-to-cord, cord-to-cortex, and plexus-to-cortex conduction times were not different between groups. These data suggest that hypertension affects the peripheral nervous system by reducing the number of active sensory nerve fibers without affecting myelination. However, hypertension does not seem to affect the afferent somatosensory pathway within the brain.