This work was supported by a Programme Grant from the Wellcome Trust. The first author is supported by a Wellcome Trust Principal Research Fellowship. We thank Genevieve McArthur for comments on an earlier draft of this manuscript.
Measurement of mismatch negativity in individuals: A study using single-trial analysis
Article first published online: 22 FEB 2010
Copyright © 2010 Society for Psychophysiological Research
Volume 47, Issue 4, pages 697–705, July 2010
How to Cite
Bishop, D. V. M. and Hardiman, M. J. (2010), Measurement of mismatch negativity in individuals: A study using single-trial analysis. Psychophysiology, 47: 697–705. doi: 10.1111/j.1469-8986.2009.00970.x
Re-use of this article is permitted in accordance with the Terms and Conditions set out at http://www3.interscience.wiley.com/authorresources/onlineopen.html.
- Issue published online: 9 JUN 2010
- Article first published online: 22 FEB 2010
- (Received March 1, 2009; Accepted July 7, 2009)
- Mismatch negativity;
- Single-trial analysis;
- Time-frequency analysis
Mismatch negativity (MMN) is measured by subtracting the averaged response to a set of standard stimuli from the averaged response to rarer deviant stimuli, and taking the amplitude of this difference wave in a given time window. This method is problematic when used to evaluate individuals, because there is no estimate of variance. We describe a new approach, in which independent components with high trial-by-trial variance are first removed. Next, each deviant response has the preceding standard response subtracted, giving a set of single trial difference waves. We illustrate this approach in analysis of MMN to brief tones in 17 adults. The best criterion for MMN combined t-test with an index of inter-trial coherence, giving significant MMN in 14 (82%) of individuals. Single-trial methods can indicate which people show MMN. However, in some clinically normal individuals there was no MMN, despite good behavioral discrimination of stimuli.