This work was supported by an Interdisciplinary FBM-UNIL grant to Maria G. Knyazeva and by a Swiss National Science Foundation grant (No. 200020-117975/1) to Mahdi Jalili. We are grateful to Prof. R. S. J. Frackowiak for his help and encouragement, Dr. S. Lavoie for EEG recording, and Ms D. Polzik for assistance in the preparation of the manuscript.
Attenuated asymmetry of functional connectivity in schizophrenia: A high-resolution EEG study
Article first published online: 22 JAN 2010
Copyright © 2010 Society for Psychophysiological Research
Volume 47, Issue 4, pages 706–716, July 2010
How to Cite
Jalili, M., Meuli, R., Do, K. Q., Hasler, M., Crow, T. J. and Knyazeva, M. G. (2010), Attenuated asymmetry of functional connectivity in schizophrenia: A high-resolution EEG study. Psychophysiology, 47: 706–716. doi: 10.1111/j.1469-8986.2009.00971.x
- Issue published online: 9 JUN 2010
- Article first published online: 22 JAN 2010
- (Received March 26, 2009; Accepted July 30, 2009)
- Laplacian EEG;
- Cerebral torque;
The interhemispheric asymmetries that originate from connectivity-related structuring of the cortex are compromised in schizophrenia (SZ). Under the assumption that such abnormalities affect functional connectivity, we analyzed its correlate—EEG synchronization—in SZ patients and matched controls. We applied multivariate synchronization measures based on Laplacian EEG and tuned to various spatial scales. Compared to the controls who had rightward asymmetry at a local level (EEG power), rightward anterior and leftward posterior asymmetries at an intraregional level (1st and 2nd order S-estimator), and rightward global asymmetry (hemispheric S-estimator), SZ patients showed generally attenuated asymmetry, the effect being strongest for intraregional synchronization in the alpha and beta bands. The abnormalities of asymmetry increased with the duration of the disease and correlated with the negative symptoms. We discuss the tentative links between these findings and gross anatomical asymmetries, including the cerebral torque and gyrification pattern, in normal subjects and SZ patients.