The project described was supported by NIH Grant R21 NS057821 from NINDS and NIAMS, with additional support provided by a Catalyst Grant from the University of Utah, by NIH Grant R21 AT002209 from NCAM and by the CFIDS Association.
Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome
Article first published online: 4 MAR 2010
Copyright © 2010 Society for Psychophysiological Research
Volume 47, Issue 4, pages 615–624, July 2010
How to Cite
White, A. T., Light, A. R., Hughen, R. W., Bateman, L., Martins, T. B., Hill, H. R. and Light, K. C. (2010), Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome. Psychophysiology, 47: 615–624. doi: 10.1111/j.1469-8986.2010.00978.x
[Correction added after online publication March 4, 2010: in Figure 1 and Table 2, several asterisks were missing.]
- Issue published online: 9 JUN 2010
- Article first published online: 4 MAR 2010
- (Received April 13, 2009; Accepted August 17, 2009)
- Chronic fatigue syndrome;
Chronic fatigue syndrome (CFS) patients often report symptom flare (SF) for >24 h after moderate exercise (post-ex). We hypothesized that SF is linked to increases in circulating cytokines and CD40 Ligand (CD40L). In 19 CFS patients and 17 controls, mental and physical fatigue and pain symptom ratings were obtained together with serum for 11 cytokines and CD40L before and at 0.5, 8, 24, and 48 h post-ex. Before exercise, CFS had lower CD40L (p<.05) but similar cytokines versus controls. In subgroups based on SF at 48 h, high SF patients (n=11) increased in IL-1β, IL-12, IL-6, IL-8, IL-10, and IL-13 (p<.05) 8 h post-ex. Low SF patients (n=8) showed post-ex decreases in IL-10, IL-13, and CD40L, and controls decreased in IL-10, CD40L, and TNFα (p<.05). Thus, in CFS, cytokine activity may vary directly with SF, which may explain prior inconsistent findings.