This manuscript is based on work completed by the first author in partial fulfillment of the requirements for the degree of Master of Arts at the University of Minnesota, under the supervision of the second author. The work was supported by grants MH65137, MH17069, MH072850, MH080239, MH089727, and AA12164 from the National Institutes of Health.
Operationalizing proneness to externalizing psychopathology as a multivariate psychophysiological phenotype
Article first published online: 21 JUN 2010
Copyright © 2010 Society for Psychophysiological Research
Volume 48, Issue 1, pages 64–72, January 2011
How to Cite
Nelson, L. D., Patrick, C. J. and Bernat, E. M. (2011), Operationalizing proneness to externalizing psychopathology as a multivariate psychophysiological phenotype. Psychophysiology, 48: 64–72. doi: 10.1111/j.1469-8986.2010.01047.x
- Issue published online: 9 DEC 2010
- Article first published online: 21 JUN 2010
- (Received September 8, 2009; Accepted February 3, 2010)
- Feedback-related negativity;
- Event-related potential
The externalizing dimension is viewed as a broad dispositional factor underlying risk for numerous disinhibitory disorders. Prior work has documented deficits in event-related brain potential (ERP) responses in individuals prone to externalizing problems. Here, we constructed a direct physiological index of externalizing vulnerability from three ERP indicators and evaluated its validity in relation to criterion measures in two distinct domains: psychometric and physiological. The index was derived from three ERP measures that covaried in their relations with externalizing proneness—the error-related negativity and two variants of the P3. Scores on this ERP composite predicted psychometric criterion variables and accounted for externalizing-related variance in P3 response from a separate task. These findings illustrate how a diagnostic construct can be operationalized as a composite (multivariate) psychophysiological variable (phenotype).