IED is now at the Autism Research Unit, Hospital for Sick Children, Toronto, Ontario, and MKJ is now at the Department of Psychology, Brock University. This research was supported by a National Alliance for Autism Research (NAAR) Pre-doctoral Fellowship awarded to IED under the direction of SEB, a Natural Sciences and Engineering Research Council of Canada (NSERC) Pre-doctoral Fellowship awarded to MKJ under the direction of LAS, a Community Social and Vocational Rehabilitation (CVSR) Foundation grant awarded to JOG, a Lawson Foundation Post-doctoral Fellowship awarded to KJM under the direction of LAS, and Social Sciences and Humanities Research Council of Canada (SSHRC) and NSERC operating grants awarded to LAS. The authors would like to thank Sue McKee and Stephanie Tak for their help with data collection and the clients and staff at the Woodview Manor Independent Living Program.
An event-related source localization study of response monitoring and social impairments in autism spectrum disorder
Article first published online: 14 JUN 2010
Copyright © 2010 Society for Psychophysiological Research
Volume 48, Issue 2, pages 241–251, February 2011
How to Cite
Santesso, D. L., Drmic, I. E., Jetha, M. K., Bryson, S. E., Goldberg, J. O., Hall, G. B., Mathewson, K. J., Segalowitz, S. J. and Schmidt, L. A. (2011), An event-related source localization study of response monitoring and social impairments in autism spectrum disorder. Psychophysiology, 48: 241–251. doi: 10.1111/j.1469-8986.2010.01056.x
- Issue published online: 6 JAN 2011
- Article first published online: 14 JUN 2010
- (Received August 18, 2009; Accepted March 10, 2010)
- Response monitoring;
- Autism spectrum disorder;
- Anterior cingulate cortex
A number of studies suggest anterior cingulate cortex (ACC) abnormalities in autism spectrum disorder (ASD), which might underlie response monitoring and social impairments exhibited by children and adolescents with ASD. The goal of the present study was to extend this work by examining error and correct response monitoring using event-related potentials (ERN, Pe, CRN) and LORETA source localization in high functioning adults with ASD and controls. Adults with ASD showed reduced ERN and Pe amplitudes and reduced rostral ACC activation compared with controls. Adults with ASD also showed less differentiation between error and correct ERP components. Social impairments and higher overall autism symptoms were related to reduced rostral ACC activity at the time of the ERN, particularly in adults with ASD. These findings suggest that reduced ACC activity may reflect a putative brain mechanism involved in the origins and maintenance of social impairments and raise the possibility of the presence of stable brain-behavior relation impairment across development in some individuals with ASD.