This study was supported in part by grants MH57322, MH37705, and Center grant P50 MH066286 from the National Institute of Mental Health, Bethesda, MD. We thank Marilyn Kesler/West, Ph.D. for assistance with study procedures.
Distinct neural generators of sensory gating in schizophrenia
Article first published online: 23 AUG 2010
Copyright © 2010 Society for Psychophysiological Research
Volume 48, Issue 4, pages 470–478, April 2011
How to Cite
Williams, T. J., Nuechterlein, K. H., Subotnik, K. L. and Yee, C. M. (2011), Distinct neural generators of sensory gating in schizophrenia. Psychophysiology, 48: 470–478. doi: 10.1111/j.1469-8986.2010.01119.x
- Issue published online: 1 MAR 2011
- Article first published online: 23 AUG 2010
- (Received August 14, 2009; Accepted June 15, 2010)
- Sensory gating;
- Inhibitory deficits;
- EEG source analysis;
- Dorsolateral prefrontal cortex
Although malfunctioning of inhibitory processes is proposed as a pathophysiological mechanism in schizophrenia and has been studied extensively with the P50 gating paradigm, the brain regions involved in generating and suppressing the P50 remain unclear. The current investigation used EEG source analysis and the standard S1-S2 paradigm to clarify the neural structures associated with P50 gating in 16 schizophrenia patients and 14 healthy subjects. Based on prior research, the superior temporal gyrus, hippocampus, dorsolateral prefrontal cortex, thalamus, and their dipole moments were evaluated. In modeling the P50, a neural network involving all four brain regions provided the best goodness-of-fit across both groups. In healthy subjects, the P50 ratio score correlated positively with the hippocampal dipole moment ratio, whereas a significant association with the DLPFC dipole moment ratio was observed in schizophrenia patients. In each instance, the neural structure was found to account for unique variance in explaining the P50 ratio, along with some suggestion of DLPFC involvement in healthy subjects.