This work was supported by the regional government of Galicia, Spain (INCITE09 106 232 PR to N. F., 2009/013, 2009/002) and the Spanish Ministry of Science and Innovation (PSI2008-03175 to M. F. d. O).
Neural correlates of local contextual processing deficits in schizophrenic patients
Article first published online: 29 MAR 2011
Copyright © 2011 Society for Psychophysiological Research
Volume 48, Issue 9, pages 1217–1226, September 2011
How to Cite
Fogelson, N., Ribolsi, M., Fernandez-Del-Olmo, M., Rubino, I. A., Romeo, D., Koch, G. and Peled, A. (2011), Neural correlates of local contextual processing deficits in schizophrenic patients. Psychophysiology, 48: 1217–1226. doi: 10.1111/j.1469-8986.2011.01195.x
- Issue published online: 27 JUL 2011
- Article first published online: 29 MAR 2011
- (Received August 1, 2010; Accepted January 27, 2011)
- Neural correlate
Deficits in processing contextual information are one of the main features of cognitive dysfunction in schizophrenia, but the neurophysiologic substrate underlying this dysfunction is poorly understood. We used ERPs to investigate local contextual processing in schizophrenic patients. Local context was defined as the occurrence of a short predictive series of stimuli occurring before delivery of a target event. Response times of predicted targets were faster in controls compared to patients. Schizophrenia patients failed to generate the P3b latency shift between predicted and random targets that was observed in controls and demonstrated a prominent reduction of the peak of an early latency context dependent positivity. The current study provides evidence of contextual processing deficits in schizophrenia patients by demonstrating alteration in the behavioral and neural correlates of local contextual processing.