This research was supported under Australian Research Council's Discovery Projects funding scheme (project number DP0770568).
Age-related differences in corticospinal excitability during a Go/NoGo task
Article first published online: 1 APR 2011
Copyright © 2011 Society for Psychophysiological Research
Volume 48, Issue 10, pages 1448–1455, October 2011
How to Cite
Fujiyama, H., Tandonnet, C. and Summers, J. J. (2011), Age-related differences in corticospinal excitability during a Go/NoGo task. Psychophysiology, 48: 1448–1455. doi: 10.1111/j.1469-8986.2011.01201.x
- Issue published online: 13 SEP 2011
- Article first published online: 1 APR 2011
- (Received December 1, 2010; Accepted February 17, 2011)
- Go/NoGo reaction time;
- Corticospinal excitability;
- Intracortical inhibition;
- Transcranial magnetic stimulation
Age-related slowing of reaction times (RTs) is well documented but whether the phenomenon reflects deficits in movement preparation and/or response generation processes is unclear. To gain further insight into this issue, transcranial magnetic stimulation (TMS) was used to investigate motor cortex (M1) excitability and short-interval intracortical inhibitory (SICI) processes during a Go/NoGo RT task in younger and older adults. Single- and paired-pulse TMS was delivered over the left M1 during preparation and response generation periods in a right-hand muscle. Younger adults had shorter RTs and a larger increase in corticospinal excitability at response generation period than older adults. SICI modulation for both groups showed a large reduction in inhibition immediately prior to EMG onset. These findings indicate age-related differences in corticospinal excitability during the response generation stage of sensorimotor information processing.