Michael Karl Boettger is currently employed at Bayer Schering Pharma AG, Wuppertal, Germany.
Nonlinear relationship between electrodermal activity and heart rate variability in patients with acute schizophrenia
Article first published online: 15 APR 2011
Copyright © 2011 Society for Psychophysiological Research
Volume 48, Issue 10, pages 1323–1332, October 2011
How to Cite
Rachow, T., Berger, S., Boettger, M. K., Schulz, S., Guinjoan, S., Yeragani, V. K., Voss, A. and Bär, K.-J. (2011), Nonlinear relationship between electrodermal activity and heart rate variability in patients with acute schizophrenia. Psychophysiology, 48: 1323–1332. doi: 10.1111/j.1469-8986.2011.01210.x
- Issue published online: 13 SEP 2011
- Article first published online: 15 APR 2011
- (Received July 12, 2010; Accepted March 7, 2011)
- Mutual information;
- Electrodermal activity;
- Heart rate variability;
- Sympathetic skin response
We investigated to what degree tonic skin conductance levels (SCL) and cardiac autonomic dysfunction are interrelated in schizophrenia. Heart rate variability (HRV) and SCL were simultaneously assessed in 18 unmedicated patients and 18 controls matched for age, sex, weight, and smoking habits. For comparison to prior studies, phasic sympathetic skin responses (SPR) were also recorded. Compared to controls, patients had prolonged SPR latency and reduced SPR amplitude with a right-greater-than-left asymmetry, which was inversely correlated with positive symptoms. An autonomic imbalance was reflected in linear and nonlinear measures of HRV and increased SCL. Patients showed a stronger nonlinear association between SCL and heart rate than controls. HRV and SCL findings were strongly affected by group differences in breathing rate. Stronger HRV-SCL coupling in patients may suggest augmented sympathetic modulation in schizophrenia.