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Spatiotemporal and frequency domain analysis of auditory paired stimuli processing in schizophrenia and bipolar disorder with psychosis


  • This work was supported by grants from the National Institutes of Health (R01s MH077945, MH077862, MH077851, MH078113, and MH085485). Author MSK has served as an Ad Hoc Consultant for PureTech Ventures, Eli Lilly Pharmaceuticals, Sunovion Pharmaceuticals Inc., Astellas Pharma US Inc., and Merck & Company, Inc. and has served on the advisory board for Intracellular Therapies Inc. Author JAS has served as a consultant for Takeda, Inc., Pfizer, Inc., and Eli Lilly Pharmaceuticals and has received grant funding from Janssen, Inc.

Address correspondence to: Brett A. Clementz, University of Georgia, Psychology Department, Psychology Building, Athens, GA 30602-3013, USA. E-mail:


Individuals with schizophrenia (SZ) or bipolar disorder with psychosis (BPP) may share neurophysiological abnormalities as measured in auditory paired-stimuli paradigms with electroencephalography (EEG). Such investigations have been limited, however, by quantifying only event-related potential peaks and/or broad frequency bands at limited scalp locations without considering possible mediating factors (e.g., baseline differences). Results from 64-sensor EEG collected in 180 age- and gender-matched participants reveal (i) accentuated prestimulus gamma oscillations and (ii) reduced P2 amplitudes and theta/alpha oscillations to S1 among participants with both SZ and BPP. Conversely, (iii) N1s in those with SZ to S1 were reduced compared to healthy volunteers and those with BPP, whereas (iv) beta range oscillations 200–300 ms following S2 were accentuated in those with BPP but not those with SZ. Results reveal a pattern of both unique and shared neurophysiological phenotypes occurring within major psychotic diagnoses.

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