AN EVALUATION OF HUMORAL ANTIBODY RESPONSES IN PATIENTS WITH CARCINOMA OF THE CERVIX

  1. G. H. Vos1,
  2. M. G. Hammond1,
  3. D. Vos1,
  4. B. G. Grobbelaar1,
  5. H. P. Auslander2,†,
  6. G. Marescotti2,†

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1972.tb11883.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 79, Issue 11, pages 1040–1046, November 1972

Additional Information

How to Cite

Vos, G. H., Hammond, M. G., Vos, D., Grobbelaar, B. G., Auslander, H. P. and Marescotti, G. (1972), AN EVALUATION OF HUMORAL ANTIBODY RESPONSES IN PATIENTS WITH CARCINOMA OF THE CERVIX. BJOG: An International Journal of Obstetrics & Gynaecology, 79: 1040–1046. doi: 10.1111/j.1471-0528.1972.tb11883.x

Author Information

  1. 1

    Natal Institute of Immunology, 149 Prince Street, Durban, South Africa

  2. 2

    Department of Obstetrics and Gynaecology, University of Natal Medical School, Durban, South Africa

  1. †

    Department of Health and Rehabilitative Services, Jacksonville, 32201, Florida, U.S.A.

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

Tumour tissue from patients with inoperable cervical carcinoma was studied to determine the significance of humoral antibody involvement. Comparative elution studies using normal and cancerous tissues revealed that various classes of immunoglobulin and complement, either singly or in combination could only be recovered from the cancerous tissues. Some cancer tissue eluates possessed antibodies which sensitized normal lymphocytes by the cytotoxicity test suggesting the host's recognition of structural modification of the tumour cell. It is possible that the various classes of immunoglobulin found in cancer tissue eluates represent antibodies to cytoplasmic constituents, cell membranes or antigen-antibody complexes. It was found that the serum from the cancer patients possessed a significantly higher incidence of “non specific” lymphocytotoxic antibodies than the controls. Our inability to associate these antibodies with specificities for normal histocompatibility antigens suggests that this type of antibody may symbolize humoral responses towards a combination of tumour-related and normal transplantation antigens. It seems apparent that their activity is of an autoimmune nature capable of altering the in vivo functions of the cell-mediated immune mechanism.

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