THE EFFECT OF DEXAMETHASONE ON THE EXCRETION OF MATERNAL URINARY STEROIDS IN PREGNANCIES WITH ANENCEPHALIC FETUSES

  1. Sati C. Chattoraj,
  2. Jack L. Pinkus,
  3. John A. Stronge,
  4. Adrian K. Turner,
  5. David Charles

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1972.tb11889.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 79, Issue 12, pages 1080–1086, December 1972

Additional Information

How to Cite

Chattoraj, S. C., Pinkus, J. L., Stronge, J. A., Turner, A. K. and Charles, D. (1972), THE EFFECT OF DEXAMETHASONE ON THE EXCRETION OF MATERNAL URINARY STEROIDS IN PREGNANCIES WITH ANENCEPHALIC FETUSES. BJOG: An International Journal of Obstetrics & Gynaecology, 79: 1080–1086. doi: 10.1111/j.1471-0528.1972.tb11889.x

Author Information

  1. Department of Obstetrics and Gynecology, Boston University School of Medicine and Boston City Hospital, Boston, Massachusetts 02118, U.S.A. and National Maternity Hospital, Dublin, Ireland

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

The urinary excretions of oestriol, total 17-oxosteroids and pregnanediol were studied before, during and after the administration of dexamethasone in 14 pregnancies in which the fetus was anencephalic. While the excretion of oestriol in all patients decreased significantly during therapy no consistent alteration was observed either for total 17-oxosteroids or pregnanediol. In eight of these patients fractionation of oestrogens and 11-deoxy-17-oxosteroids was carried out. A consistent and significant decrease in values of oestrone, oestriol and dehydroepiandrosterone (DHA) was observed. The effect of dexamethasone on the excretion of oestradiol-17β and the 17-oxosteroids, androsterone and aetiocholanolone was insignificant.

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