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THE EFFECTS OF A PROGESTOGEN, MEGESTROL ACETATE, ON CARBOHYDRATE AND LIPID METABOLISM
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1972.tb12911.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 79, Issue 8, pages 744–752, August 1972
Additional Information
How to Cite
Adams, P. W. and Wynn, V. (1972), THE EFFECTS OF A PROGESTOGEN, MEGESTROL ACETATE, ON CARBOHYDRATE AND LIPID METABOLISM. BJOG: An International Journal of Obstetrics & Gynaecology, 79: 744–752. doi: 10.1111/j.1471-0528.1972.tb12911.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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Summary
The metabolic effects of the administration of megestrol acetate 0.5 mg. daily have been studied in 31 women. In 26 women (Group A) studied before and after daily megestrol acetate administration there were no changes in plasma glucose, plasma insulin, blood pyruvate, serum triglyceride and serum cholesterol levels. Significant decreases in plasma glucose and plasma insulin and in blood pyruvate levels during oral and intravenous glucose tolerance tests were observed in 17 women (Group B) on substituting daily megestrol acetate for a combined oestrogen-progestogen oral contraceptive (OC). In these women the fasting serum triglyceride and serum cholesterol levels also decreased. It is concluded that the daily administration of 0.5 mg. megestrol acetate does not alter carbohydrate or lipid metabolism. This may be an advantage over combined preparations. Offsetting this, however, was a fairly high incidence of side effects and in this small group, at least one method failure.