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RING CHROMOSOMES IN CARCINOMA IN SITU OF THE CERVIX AS EVIDENCE OF CLONAL GROWTH
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1972.tb12930.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 79, Issue 9, pages 833–840, September 1972
Additional Information
How to Cite
Spriggs, A. I. and Cowdell, R. H. (1972), RING CHROMOSOMES IN CARCINOMA IN SITU OF THE CERVIX AS EVIDENCE OF CLONAL GROWTH. BJOG: An International Journal of Obstetrics & Gynaecology, 79: 833–840. doi: 10.1111/j.1471-0528.1972.tb12930.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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- Cited By
Summary
Two cases are described in which ring chromosomes were found in direct preparations of cervical epithelium showing presumptive precancerous states. Both showed “microcarcinoma”, though not in parts of the cervix from which samples for chromosomes were obtained. Similar ring chromsomes were seen in separate biopsy samples, demonstrating the extension of an abnormal clone. Failure of rings to separate at anaphase produced bridges visible in histological sections, and (in one case) in millipore preparations taken from the living cervix, and this confirmed the wide extent of spread of the neoplastic clone.