Department of Human Reproduction and Obstetrics, University of Southampton.
1471-0528/asset/BJO_left.gif?v=1&s=0fb87361cdb6be25fdf05019eed6d47f5143f610)
1471-0528/asset/olbannerright.gif?v=1&s=3892ef16ff18d6834c302faf85268a49f5fc588f)
HYPOTHALAMO-PITUITARY-ADRENAL FUNCTION DURING ORAL CONTRACEPTIVE THERAPY WITH COMBINED PREPARATIONS OESTROGEN-PROGESTOGEN AND PROGESTOGEN-ONLY PREPARATIONS
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1972.tb14198.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 79, Issue 6, pages 544–549, June 1972
Additional Information
How to Cite
Daly, J. R. and Elstein, M. (1972), HYPOTHALAMO-PITUITARY-ADRENAL FUNCTION DURING ORAL CONTRACEPTIVE THERAPY WITH COMBINED PREPARATIONS OESTROGEN-PROGESTOGEN AND PROGESTOGEN-ONLY PREPARATIONS. BJOG: An International Journal of Obstetrics & Gynaecology, 79: 544–549. doi: 10.1111/j.1471-0528.1972.tb14198.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Plasma corticosteroid levels and the urinary excretion of 17-0x0 and 17-oxogenic steroids have been determined in a group of healthy women taking combined oestrogen-progestogen oral contraceptives. The results have been compared with those obtained in untreated patients and in a group taking preparations containing only progestogens (the mini pill). The marked changes produced by the combined preparations are not seen with the mini pill which does not appear to affect cortisol metabolism. Dynamic tests of hypothalamo-pituitary-adrenal function (the assessment of the nyctohemeral rhythm of plasma corticosteroids and urinary free cortisol, ACTH stimulation, insulin-hypoglycaemia and dexamethasone suppression tests) showed no abnormality in patients taking either the combined pill or the mini pill.