THE EFFECTS OF DIAZEPAM ON THE FETUS

  1. J. Scher Exchange Registrar1,†,
  2. D. M. Hailey1,
  3. R. W. Beard Senior Lecturer2,‡

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1972.tb14213.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 79, Issue 7, pages 635–638, July 1972

Additional Information

How to Cite

Scher, J., Hailey, D. M. and Beard, R. W. (1972), THE EFFECTS OF DIAZEPAM ON THE FETUS. BJOG: An International Journal of Obstetrics & Gynaecology, 79: 635–638. doi: 10.1111/j.1471-0528.1972.tb14213.x

Author Information

  1. 1

    Roche Research Unit, Liverpool

  2. 2

    Kings College Hospital, London, S. E.5

  1. †

    Now Lecturer in Obstetrics and Gynaecalogy, Groote Schuur Hospital, University of Cape Town.

  2. ‡

    Now Professor of Obstetrics and Gynaecology, St. Mary's Hospital, London.

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

Diazepam causes loss of beat-to-beat variation of the fetal heart rate pattern within two minutes of the intravenous administration of 20 mg. This effect lasts an average of 65 minutes. This is not associated with a significant alteration of fetal pH or Apgar score at birth, High fetal plasma levels do not appear to affect the fetus adversely in labour or at birth. Rapid placental transfer occurs and the maternal and fetal blood ratios are variable.

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