THE EFFECTS OF HYPOXIA ON HYDROXYSTEROID DEHYDROGENASE ACTIVITY IN PLACENTAL VILLI MAINTAINED IN ORGAN CULTURE

  1. Frank Sharp Lecturer1,
  2. MatthewJ. Carty Registrar2,
  3. Hamish Young Chief Technician3

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1972.tb15747.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 79, Issue 1, pages 44–49, January 1972

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How to Cite

Sharp, F., Carty, MatthewJ. and Young, H. (1972), THE EFFECTS OF HYPOXIA ON HYDROXYSTEROID DEHYDROGENASE ACTIVITY IN PLACENTAL VILLI MAINTAINED IN ORGAN CULTURE. BJOG: An International Journal of Obstetrics & Gynaecology, 79: 44–49. doi: 10.1111/j.1471-0528.1972.tb15747.x

Author Information

  1. 1

    University Department of Obstetrics, Queen Mother's Hospital, Glasgow

  2. 2

    Queen Mother's Hospital, Glasgow C.3

  3. 3

    University Department of Dermatology, Anderson College, Glasgow W.2

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

Hydroxysteroid dehydrogenase (HSD) enzyme activity has been studied histochemically in placental villi maintained in organ culture, some under fully oxygenated conditions and some under conditions of hypoxia. HSD activity was diminished in hypoxia. The process is apparently selective, with trophoblastic activity more sensitive than that in villous core, and 3β-HSD more so than 17β-HSD. Also, with 17β-HSDs, activity using oestradiol-17β as substrate was more sensitive than that using testosterone as substrate. The possible correlation with the clinical picture in placental insufficiency is discussed.

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