ELECTROENCEPHALOGRAPHIC CHANGES AFTER INTRAAMNIOTIC PROSTAGLANDIN F2α AND HYPERTONIC SALINE

  1. R. P. Shearman,
  2. R. C. Lyneham,
  3. J. C. Walsh,
  4. D. Itzkowic,
  5. D. A. Shutt

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1975.tb00641.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 82, Issue 4, pages 314–317, April 1975

Additional Information

How to Cite

Shearman, R. P., Lyneham, R. C., Walsh, J. C., Itzkowic, D. and Shutt, D. A. (1975), ELECTROENCEPHALOGRAPHIC CHANGES AFTER INTRAAMNIOTIC PROSTAGLANDIN F2α AND HYPERTONIC SALINE. BJOG: An International Journal of Obstetrics & Gynaecology, 82: 314–317. doi: 10.1111/j.1471-0528.1975.tb00641.x

Author Information

  1. Department of Obstetrics and Gynaecology University of Sydney, King George V Memorial Hospital and Royal Prince Alfred Hospital, Sydney, Australia

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

Six major convulsions have been seen among 555 patients who had therapeutic second trimester abortion by intra-amniotic prostaglandin F2α (PGF2α). Five of 21 patients receiving intra-amniotic hypertonic saline and 5 of 16 patients receiving PGF2α showed abnormalities in electroencephalograms after treatment. These changes were relatively minor in all saline patients and in three receiving PGF2α, but two patients receiving PGF2α showed epileptiform spike activity after infusion. There was no correlation between the electroencephalographic (EEG) changes and peripheral venous levels of PGF2α or its metabolite, 13, 14 dihydro-15 keto PGF2α (15 keto-h2-F2α).

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