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FAILURE OF HEPARIN THERAPY TO AFFECT THE CLINICAL COURSE OF SEVERE PRE-ECLAMPSIA
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1975.tb00711.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 82, Issue 9, pages 711–717, September 1975
Additional Information
How to Cite
Howie, P. W., Prentice, C. R. M. and Forbes, C. D. (1975), FAILURE OF HEPARIN THERAPY TO AFFECT THE CLINICAL COURSE OF SEVERE PRE-ECLAMPSIA. BJOG: An International Journal of Obstetrics & Gynaecology, 82: 711–717. doi: 10.1111/j.1471-0528.1975.tb00711.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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- Cited By
Summary
In view of the association between pre-eclampsia and disseminated intravascular coagulation, three patients presenting with severe pre-eclampsia before the 28th week of pregnancy were treated with heparin. In all three patients, there was deterioration of hypertension and proteinuria that necessitated the withdrawal of treatment after five to six days. During treatment, serum and urinary fibrinolytic degradation products (FDPs) continued to rise or remained unaltered, plasminogen levels showed a steady fall, and the platelet count remained at a reduced level. These data suggest that heparin was an ineffective form of treatment and did not prevent the intravascular fibrin deposition associated with severe pre-eclampsia.