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METABOLISM OF PROSTAGLANDIN F2α WITHIN THE HUMAN UTERUS IN EARLY PREGNANCY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1975.tb02212.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 82, Issue 2, pages 142–145, February 1975
Additional Information
How to Cite
Keires, M. J. N. C., Williamson, J. G. and Turnbul, A. C. (1975), METABOLISM OF PROSTAGLANDIN F2α WITHIN THE HUMAN UTERUS IN EARLY PREGNANCY. BJOG: An International Journal of Obstetrics & Gynaecology, 82: 142–145. doi: 10.1111/j.1471-0528.1975.tb02212.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
The potential for intra-uterine metabolism of prostaglandins in early pregnancy was studied by incubation of prostaglandin F2α (PGF2α) with tissues obtained by termination hysterectomy at 7 and 16 weeks gestation. Enzymes regulating the degradation of prostaglandins were demonstrated in placenta and membranes and to a lesser extent, in myometrium and decidua. It is believed that these enzymes may have a physiological rôle in maintaining the continuity of pregnancy, and that the high degradation of PGF2α in placenta and membranes may be one of the reasons that, for termination of pregnancy, far higher doses are required intra-amniotically than extra-amniotically.