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MATERNAL PLASMA ALPHA-FETOPROTEIN IN NORMAL AND COMPLICATED PREGNANCIES
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1976.tb00725.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 83, Issue 1, pages 24–32, January 1976
Additional Information
How to Cite
Rodeck, C. H., Campbell, S. and Biswas, S. (1976), MATERNAL PLASMA ALPHA-FETOPROTEIN IN NORMAL AND COMPLICATED PREGNANCIES. BJOG: An International Journal of Obstetrics & Gynaecology, 83: 24–32. doi: 10.1111/j.1471-0528.1976.tb00725.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Plasma alpha-fetoprotein (AFP) has been estimated by radioimmunoassay in healthy non-pregnant adults, some of whom were taking oral contraceptives, and in women with normal and complicated pregnancies. A curve with the 90 per cent range in normal pregnancy was established. The proportion of values below the 5th centile in complicated pregnancies was significantly greater than in uncomplicated pregnancies. However, three-quarters of the estimations in the complicated groups lay within the 90 per cent range. No correlation was found between maternal plasma AFP values and the incidence of fetal distress, small-for-dates babies or perinatal mortality. It is concluded that the measurement of maternal plasma AFP is not a reliable test for predicting fetal well-being.