PLASMA LEVELS OF PREGNANCY–SPECIFIC β1–GLYCOPROTEIN IN NORMAL PREGNANCY

  1. C. M. Towler Research Fellow in Pathology 1,
  2. C. H. W. Horne Senior Lecturer in Pathology 1,
  3. V. Jandial Senior Registrar in Obstetrics and Gynaecology 2,
  4. Doris M. Campbell Lecturer in Obstetrics, Gynaecology and Physiology 2,
  5. I. MacGillivray Regius Professor of Obstetrics and Gynaecology 2

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1976.tb00743.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 83, Issue 10, pages 775–779, October 1976

Additional Information

How to Cite

Towler, C. M., Horne, C. H. W., Jandial, V., Campbell, D. M. and MacGillivray, I. (1976), PLASMA LEVELS OF PREGNANCY–SPECIFIC β1–GLYCOPROTEIN IN NORMAL PREGNANCY. BJOG: An International Journal of Obstetrics & Gynaecology, 83: 775–779. doi: 10.1111/j.1471-0528.1976.tb00743.x

Author Information

  1. 1

    Department of Pathology, University Medical School, Foresterhill, Aberdeen

  2. 2

    Department of Obstetrics and Gynaecology, Aberdeen Maternity Hospital Foresterhill, Aberdeen

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

Pregnancy-specific β1–glycoprotein (PSβG) is a major product of the trophoblast which has only recently been identified. Like human placental lactogen, the concentration of PSβG in maternal blood rises throughout pregnancy until about 34 weeks, thereafter tending to remain constant until term, with only a small day-to-day variation in individuals. The circulating maternal levels of PSβG between 34 weeks and term are about 200 μg/ml, 20 to 30 times greater than the levels of placental lactogen, thus allowing detection and measurement of PSβG by relatively simple techniques. The levels of PSβG are above the normal range in the majority of twin pregnancies. It is suggested that PSβG measurements may be useful in assessing placental function and may help in the detection of multiple pregnancies at an early stage of gestation.

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