STUDIES IN THE INVOLVEMENT OF PROSTAGLANDINS IN UTERINE SYMPTOMATOLOGY AND PATHOLOGY

  1. Eve A. Willman,
  2. W. P. Collins,
  3. S. G. Clayton

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1976.tb00839.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 83, Issue 5, pages 337–341, May 1976

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How to Cite

Willman, E. A., Collins, W. P. and Clayton, S. G. (1976), STUDIES IN THE INVOLVEMENT OF PROSTAGLANDINS IN UTERINE SYMPTOMATOLOGY AND PATHOLOGY. BJOG: An International Journal of Obstetrics & Gynaecology, 83: 337–341. doi: 10.1111/j.1471-0528.1976.tb00839.x

Author Information

  1. Department of Obstetrics and Gynaecology and WHO Collaborating Centre for Clinical Research on Human Reproduction King's College Hospital Medical School, Denmark Hill, London SE5 8RX

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

The concentrations of prostaglandins E2 and Fα were measured by radioimmunoassay in samples of endometrial tissue from 155 women. The results showed that the concentration of prostaglandin E2 (ng/100 mg of wet tissue; mean ± SD) in tissue from apparently healthy women with regular menstrual cycles was 79·3 ± 9·9 during the menstrual period. The level in the proliferative and early secretory phases fell to 11·8 ± 4·0 and 13·3± 8·3 respectively. During the late secretory phase there was a significant increase to 20·1±10·8. The corresponding values from patients with fibromyomata and without menorrhagia were similar. However, the concentration in tissue from patients with fibromyomata and menorrhagia was significantly higher (63·9 ±17·9) during the secretory phase of the uterine cycle. In addition, the amount was significantly higher in the groups with dysmenorrhoea (19 ·0 ± 4·5 proliferative; 68 · 0 ± 18 ·15 secretory) and irregular uterinbleeding (78·3 ± 59·0 proliferative; 87·4 ± 64·9 secretory). The mean concentration was higher in cases of endometriosis, and significantly elevated in endometrial carcinoma. The results for prostaglandin Fα showed a similar pattern, but the changes were less marked in patients with irregular dysfunctional bleeding. The findings are discussed.

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