Associate Professor of Obstetrics and Gynaecology, University of West Virginia, USA.
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TISSUE OXYGENATION AND RED CELL 2,3 DIPHOSPHOGLYCERATE IN NORMAL AND ABNORMAL PREGNANCY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1976.tb00846.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 83, Issue 5, pages 378–382, May 1976
Additional Information
How to Cite
Maclennan, A. H., Emerson, P. M., Hunter, D. J. S. and Darley, J. H. (1976), TISSUE OXYGENATION AND RED CELL 2,3 DIPHOSPHOGLYCERATE IN NORMAL AND ABNORMAL PREGNANCY. BJOG: An International Journal of Obstetrics & Gynaecology, 83: 378–382. doi: 10.1111/j.1471-0528.1976.tb00846.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Maternal tissue oxygenation as reflected by the level of red cell, 2,3-diphosphoglycerate (DPG) was measured before, during and after normal pregnancy. Following an initial fall at the beginning of pregnancy there was a significant rise in the mean level of DPG during pregnancy with an abrupt fal in the puerperium. The mean red cell DPG level in the third trimester of pregnancies complicated by pre-eclampsia and diabetes was not statistically different from the normal but the mean value of all pregnancies in which the fetus was stillborn or growth retarded was significantly lower (p<0.001). The possible mechanism of the changes in normal and abnormal pregnancy is discussed and it is suggested that the measurement of red cell DPG in the third trimester of pregnancy may prove to be a useful parameter of placental oxygenation.