Department of Obstetrics and Gynaecology, Royal United Hospital, Coombe Park, Bath.
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MONOAMINE OXIDASE ACTIVITY IN THE FETAL LUNG AND LIVER
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1976.tb00867.x
Issue
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BJOG: An International Journal of Obstetrics & Gynaecology
Volume 83, Issue 6, pages 464–469, June 1976
Additional Information
How to Cite
Jones, J. B., Papadaki, L. and Hubbard, J. (1976), MONOAMINE OXIDASE ACTIVITY IN THE FETAL LUNG AND LIVER. BJOG: An International Journal of Obstetrics & Gynaecology, 83: 464–469. doi: 10.1111/j.1471-0528.1976.tb00867.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Monoamine oxidase (MAO) in lung and liver is important in the degradation of circulating 5-hydroxytryptamine. These sites of MAO activity have been investigated histochemically in the human fetus of 12 to 18 weeks gestation. Enzyme activity could be demonstrated in the liver by both tryptamine and adrenaline oxidation. In the lung, MAO activity was present only when adrenaline was used as substrate. It may be, therefore, that in the premature baby the capacity of MAO to metabolize 5-hydroxytryptamine is not fully developed, which could lead to deleterious effects on pulmonary function.