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EFFECT OF ORAL 17-β-OESTRADIOL ON THE LIVER IN WOMEN WITH INTRAHEPATIC CHOLESTASIS (HEPATOSIS) DURING PREVIOUS PREGNANCY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1976.tb00887.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 83, Issue 7, pages 567–571, July 1976
Additional Information
How to Cite
Jeppsson, S. and Rannevik, G. (1976), EFFECT OF ORAL 17-β-OESTRADIOL ON THE LIVER IN WOMEN WITH INTRAHEPATIC CHOLESTASIS (HEPATOSIS) DURING PREVIOUS PREGNANCY. BJOG: An International Journal of Obstetrics & Gynaecology, 83: 567–571. doi: 10.1111/j.1471-0528.1976.tb00887.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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- Cited By
Summary
The effects of 17-β-oestradiol in 14 women who had had intrahepatic cholestasis of pregnancy (hepatosis) were studied. This natural oestrogen was given orally in a daily dose of 5 mg for two 20-day periods with a 7-day interval between courses. The bromsulphthalein (BSP) retention rose during the treatment, but only occasionally to levels above the upper limit of normal. Other conventional liver function tests did not usually become abnormal. In a previous investigation in the same type of patients, we studied the effects of mestranol (a synthetic 17-alky- lated oestrogen) in a daily dose of 0·1 mg with the same dose-schedule as the present investigation and 17-β-oestradiol appeared to impair liver function less than mestranol. It might thus be safer to use 17-β-oestradiol as a therapeutic agent.