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THE EFFECT OF NORMAL PREGNANCY UPON THE RENAL HANDLING OF URIC ACID
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1977.tb12459.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 84, Issue 1, pages 13–21, January 1977
Additional Information
How to Cite
Dunlop, W. and Davison, J. M. (1977), THE EFFECT OF NORMAL PREGNANCY UPON THE RENAL HANDLING OF URIC ACID. BJOG: An International Journal of Obstetrics & Gynaecology, 84: 13–21. doi: 10.1111/j.1471-0528.1977.tb12459.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Twenty-four women were investigated serially during and after normal pregnancy. Plasma uric acid concentration appeared to be inversely related to uric acid clearance under infusion conditions, and comparison with simultaneous inulin clearance suggested an alteration in renal function resulting in increased ‘net tubular reabsorption’ of uric acid as pregnancy progressed. No difference was detected between primigravidae and multigravidae. The implications of these changes are discussed with reference to the renal handling of uric acid in pre-eclampsia.