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SEQUENTIAL STUDIES IN PRE-ECLAMPSIA USING PLASMA FIBRINOGEN CHROMATOGRAPHY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1977.tb12520.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 84, Issue 12, pages 909–918, December 1977
Additional Information
How to Cite
McKiLLOP, C. A., Howie, P. W., Forbes, C. D. and Prentice, C. R. M. (1977), SEQUENTIAL STUDIES IN PRE-ECLAMPSIA USING PLASMA FIBRINOGEN CHROMATOGRAPHY. BJOG: An International Journal of Obstetrics & Gynaecology, 84: 909–918. doi: 10.1111/j.1471-0528.1977.tb12520.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
The technique of plasma fibrinogen chromatography was used to study sequential changes in coagulant and fibrinolytic activity in six patients with severe pre-eclampsia. Plasma soluble fibrinogen-fibrin complex and plasma fibrinogen-fibrin degradation product levels were measured as indices of coagulant and fibrinolytic activity respectively. Clinical deterioration antenatally was accompanied by increasing coagulant and decreasing fibrinolytic activity, while a more stable clinical picture was associated with steady coagulant and increasing fibrinolytic activity. Following delivery, a surge in fibrinolytic activity accompanied or preceded clinical recovery. The pattern of increased coagulant and diminished fibrinolytic activity would seem to favour the development of disseminated intravascular coagulation in these patients and it is possible that the balance between coagulant and fibrinolytic activity may influence the clinical course and outcome of the Pregnancy