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INCREASE OF THE PROSTAGLANDIN PRECURSOR, ARACHIDONIC ACID, IN AMNIOTIC FLUID DURING SPONTANEOUS LABOUR

  1. M. J. N. C. Keirse1,
  2. B. R. Hicks2,
  3. M. D. Mitchell2,
  4. A. C. Turnbull2

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1977.tb12524.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 84, Issue 12, pages 937–940, December 1977

Additional Information

How to Cite

Keirse, M. J. N. C., Hicks, B. R., Mitchell, M. D. and Turnbull, A. C. (1977), INCREASE OF THE PROSTAGLANDIN PRECURSOR, ARACHIDONIC ACID, IN AMNIOTIC FLUID DURING SPONTANEOUS LABOUR. BJOG: An International Journal of Obstetrics & Gynaecology, 84: 937–940. doi: 10.1111/j.1471-0528.1977.tb12524.x

Author Information

  1. 1

    Department of Obstetrics and Gynaecology, University of Leiden, University Hospital Rijnsburgerweg 10, Leiden, The Netherlands

  2. 2

    Nuffield Department of Obstetrics and Gynaecology, University of Oxford John Radcliffe Hospital, Headington, Oxford OX3 9DU

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

Concentrations of free arachidonic acid have been measured by gas liquid chromatography in amniotic fluid obtained during spontaneous labour at term. Levels of arachidonic acid ranged from 0·14 to 2·2 μg/ml and increased significantly (P<0·01) with advancing cervical dilatation. Concentrations of arachidonic acid showed no significant relation to concentrations of either prostaglandin F or 13,14-dihydro-15-keto-prostaglandin F. These findings are discussed with respect to the role of arachidonic acid in the control of prostaglandin biosynthesis during human parturition.

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