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OESTROGEN EXCRETION AND OVARIAN PATHOLOGY IN POSTMENOPAUSAL WOMEN WITH ATYPICAL HYPERPLASIA, ADENOCARCINOMA AND MIXED ADENOSQUAMOUS CARCINOMA OF THE ENDOMETRIUM
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1977.tb12533.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 84, Issue 2, pages 88–97, February 1977
Additional Information
How to Cite
Rome, M., Brown, J. B., Mason, T., Smith, M. A., Laverty, C. and Fortune, D. (1977), OESTROGEN EXCRETION AND OVARIAN PATHOLOGY IN POSTMENOPAUSAL WOMEN WITH ATYPICAL HYPERPLASIA, ADENOCARCINOMA AND MIXED ADENOSQUAMOUS CARCINOMA OF THE ENDOMETRIUM. BJOG: An International Journal of Obstetrics & Gynaecology, 84: 88–97. doi: 10.1111/j.1471-0528.1977.tb12533.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Urinary oestrogen and pregnanediol excretion were measured before and after hysterectomy and bilateral salpingo-oophorectomy in 26 postmenopausal women with adenocarcinoma of the endometrium, 10 postmenopausal women with mixed adenosquamous carcinoma and 11 postmenopausal women with atypical hyperplasia (the patient groups). The results were compared with the values obtained in 22 active postmenopausal women, 20 hospitalized postmenopausal women and 18 women who had been subjected to hysterectomy and bilateral salpingo-oophorectomy for cancer of the cervix (the control groups). The ovaries and Fallopian tubes obtained at operation were examined for evidence of current or past excessive oestrogen production. Preoperative oestrogen values were higher in the patient groups than in the controls and the elevated values persisted after oophorectomy. The implications of these findings are discussed.