McGill University, Department of Obstetrics and Gynaecology, Women's Pavilion, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada.
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CHANGES IN THE CONCENTRATION OF CORTISOL IN AMNIOTIC FLUID AFTER INTRA-AMNIOTIC PROSTAGLANDIN FOR MIDTRIMESTER ABORTION
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1977.tb12663.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 84, Issue 8, pages 608–612, August 1977
Additional Information
How to Cite
MacKenzie, I. Z., Pooley, G. and Challis, J. R. G. (1977), CHANGES IN THE CONCENTRATION OF CORTISOL IN AMNIOTIC FLUID AFTER INTRA-AMNIOTIC PROSTAGLANDIN FOR MIDTRIMESTER ABORTION. BJOG: An International Journal of Obstetrics & Gynaecology, 84: 608–612. doi: 10.1111/j.1471-0528.1977.tb12663.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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Summary
The effects of intra-amniotic prostaglandin E2 (PGE2) and PGF2a on the concentration of cortisol in amniotic fluid and in maternal peripheral plasma of patients undergoing abortion between 16 and 23 weeks gestation have been examined. There was a significant (P≤0·01) increase in the concentration of cortisol in amniotic fluid four hours after PGE2, but not after PGF2a. The concentration of cortisol in the maternal peripheral plasma increased in both groups with the progression of abortion, but the levels were not significantly correlated with those in amniotic fluid. These results suggest that by mid-pregnancy fetal cortisol production can be stimulated by PGE2 but the mechanism of this action remains to be elucidated.