ARC Institute of Animal Physiology, Babraham, Cambridge.
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PROSTAGLANDINS IN THE HUMAN UMBILICAL CIRCULATION AT BIRTH
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1978.tb10463.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 85, Issue 2, pages 114–118, February 1978
Additional Information
How to Cite
Mitchell, M. D., Brunt, J., Bibby, J., Flint, A. P. F., Anderson, A. B. M. and Turnbull, A. C. (1978), PROSTAGLANDINS IN THE HUMAN UMBILICAL CIRCULATION AT BIRTH. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 114–118. doi: 10.1111/j.1471-0528.1978.tb10463.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Prostaglandin E (PGE), prostaglandin F (PGF) and 13, 14-dihydro-15-keto-prostaglandin F (PGFM) have been measured in umbilical cord plasma obtained immediately after delivery of the baby before clamping of the cord. In general the prostaglandin levels followed the pattern PGFM>PGE>PGF. A significant arterio-venous difference was demonstrated only for PGE with raised venous levels (P<0.01). In cord blood samples obtained from infants whose mothers had received epidural anaesthesia, no arterio-venous difference for PGE could be demonstrated although the mean levels were not significantly different from controls. The concentrations of prostaglandins in Umbilical cord plasma proximal to the placenta were found to rise continuously from the time of delivery of the baby with no significant changes after cord clamping or placental delivery. The possible physiological significance of these findings is discussed.