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THROMBOXANE B2, IN AMNIOTIC FLUID BEFORE AND DURING LABOUR

  1. M. D. Mitchell,
  2. M. J. N. C. Keirse†,
  3. Anne B. M. Anderson,
  4. A. C. Turnbull

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1978.tb14911.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 85, Issue 6, pages 442–445, June 1978

Additional Information

How to Cite

Mitchell, M. D., Keirse, M. J. N. C., M. Anderson, A. B. and Turnbull, A. C. (1978), THROMBOXANE B2, IN AMNIOTIC FLUID BEFORE AND DURING LABOUR. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 442–445. doi: 10.1111/j.1471-0528.1978.tb14911.x

Author Information

  1. Nuffield Department of Obstetrics and Gynaecology, University of Oxford John Radcliffe Hospital, Headington, Oxford OX3 9 DU

  1. †

    Department of Obstetrics and Gynaecology, University of Leiden, Medical Centre, Rijnsburgerweg 10, Leiden, The Netherlands.

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

Concentrations of thromboxane B2 (TXB2) have been measured in amniotic fluid obtained during late pregnancy and labour. Samples taken at amniocentesis contained significantly lower levels of TXB2 than samples taken by amniotomy for the induction of labour which in turn contained significantly less than when the same procedure was performed during labour. In the latter group there was no correlation between the degree of cervical dilatation and the concentration of TXB2. There was no correlation between gestational age and the concentration of TXB2 in amniotic fluid obtained at amniocentesis whereas there was a significant correlation (P<0·025) between these parameters when fluid was taken by amniotomy before labour. It is suggested that the relative activities of the enzymes responsible for the conversion of prostaglandin endoperoxides to prostaglandins, thromboxane A, and prostacyclin may be of great importance during parturition.

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