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MATERNAL SERUM ALPHA-FETOPROTEIN AND BIRTH WEIGHT IN TWIN PREGNANCIES

  1. N. J. Wald1,
  2. H. Cuckle1,
  3. G. M. Stirrat2,
  4. A. C. Turnbull2

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1978.tb14924.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 85, Issue 8, pages 582–584, August 1978

Additional Information

How to Cite

Wald, N. J., Cuckle, H., Stirrat, G. M. and Turnbull, A. C. (1978), MATERNAL SERUM ALPHA-FETOPROTEIN AND BIRTH WEIGHT IN TWIN PREGNANCIES. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 582–584. doi: 10.1111/j.1471-0528.1978.tb14924.x

Author Information

  1. 1

    ICRF Cancer Epidemiology and Clinical Trials Unit Department of the Regius Professor of Medicine Radcliffe Infirmary, Oxford OX2 6HE

  2. 2

    Nufield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Oxford OX3 9DU

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

In 102 twin pregnancies the mean birth weight of each pair showed a statistically significant negative association with maternal serum alpha-fetoprotein (AFP) levels early in pregnancy. Women with AFP levels of four or more times the median value for singleton pregnancies gave birth to infants with a median birth weight 660 g less than that of infants born to women with AFP levels between 1·0 and 1·5 times the median for singleton pregnancies. Maternal serum AFP has been shown to be an early predictor of low birth weight delivery in singleton pregnancies. Our results indicate that this is also true in twin pregnancies.

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