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TRANSFER OF DIGOXIN ACROSS THE PLACENTA AND INTO BREAST MILK
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1978.tb14929.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 85, Issue 8, pages 605–609, August 1978
Additional Information
How to Cite
Chan, V., Tse, T. F. and Wong, V. (1978), TRANSFER OF DIGOXIN ACROSS THE PLACENTA AND INTO BREAST MILK. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 605–609. doi: 10.1111/j.1471-0528.1978.tb14929.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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Summary
Eleven mothers given digoxin throughout pregnancy because of rheumatic heart disease were studied. Digoxin was identified in the placenta and, for the first time, in milk. Paired cord and maternal blood samples obtained at parturition showed lower digoxin levels in cord blood than in maternal blood. The total tissue-bound digoxin level in the placenta correlated closely with maternal digoxin levels. These findings suggest strongly the presence of a placental barrier for digoxin. Similar digoxin concentrations (0·825±0·015 nmol/l) were found in milk samples obtained daily between the third and seventh days postpartum. The half-life of digoxin in the newborn was 36·2±5·43 hours (Mean±SEM); thus all the digoxin present at birth would be excreted within 10 to 11 days.