Awarded the 1978 Edgar Gentilli Prize by the Royal College of Obstetricians and Gynaecologists, London.
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THE EFFECT OF SEX STEROIDS ON THE IN VITRO SYNTHESIS OF DNA BY MALIGNANT OVARIAN TUMOURS†
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1978.tb14933.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 85, Issue 8, pages 627–633, August 1978
Additional Information
How to Cite
Darwish, D. H. (1978), THE EFFECT OF SEX STEROIDS ON THE IN VITRO SYNTHESIS OF DNA BY MALIGNANT OVARIAN TUMOURS. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 627–633. doi: 10.1111/j.1471-0528.1978.tb14933.x
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Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
The deoxyribonucleic acid (DNA) synthesis of 12 ovarian tumours was studied by means of short term organ tissue culture, exposure to tritiated thymidine and subsequent autoradiography and visual grain counting. The DNA synthesis in each tumour was studied before and after exposure to 12 separate hormone combinations. It was found that any combination of 17β-oestradiol with either of the two progestogens used had greater inhibitory potential than when any of three hormones tested was used alone.