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ABNORMAL PLATELET FUNCTION IN PRE-ECLAMPSIA
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1978.tb15820.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 85, Issue 1, pages 28–32, January 1978
Additional Information
How to Cite
Whigham, K. A. E., Howie, P. W., Drummond, A. H. and Prentice, C. R. M. (1978), ABNORMAL PLATELET FUNCTION IN PRE-ECLAMPSIA. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 28–32. doi: 10.1111/j.1471-0528.1978.tb15820.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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Summary
Platelet behaviour was studied in groups of women suffering from mild and severe pre-eclampsia, and compared with normal pregnant and non-pregnant controls. Platelets from women with severe pre-eclampsia were less responsive than normal to a variety of aggregating agents, and this impairment was significant in response to collagen and vasopressin. Women with severe pre-eclampsia had raised plasma adenine nucleotide levels and lowered platelet 5-hydroxytryptamine levels compared with the controls. Platelets from women with mild pre-eclampsia showed only a slight difference from normal. These findings may be the result of platelets having undergone aggregation and disaggregation within the circulation, and suggest that platelets may be involved in the pathogenesis of pre-eclampsia.