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HAEMOGLOBIN AIc (GLYCOHAEMOGLOBIN) IN DIABETIC PREGNANCY: AN INDICATOR OF GLUCOSE CONTROL AND FETAL SIZE

  1. J. A. Widness1,†,
  2. H. C. Schwartz2,
  3. Diana Thompson3,
  4. C. B. Kahn4,
  5. W. Oh4,
  6. R. Schwatrz5

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1978.tb15834.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 85, Issue 11, pages 812–817, November 1978

Additional Information

How to Cite

Widness, J. A., Schwartz, H. C., Thompson, D., Kahn, C. B., Oh, W. and Schwatrz, R. (1978), HAEMOGLOBIN AIc (GLYCOHAEMOGLOBIN) IN DIABETIC PREGNANCY: AN INDICATOR OF GLUCOSE CONTROL AND FETAL SIZE. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 812–817. doi: 10.1111/j.1471-0528.1978.tb15834.x

Author Information

  1. 1

    Sections of Developmental Medicine and Haematology

  2. 2

    Department of Paediatrics Stanford University School of Medicine Stanford, California 94305

  3. 3

    Sections of Medicine and of Reproductive and Developmental Medicine Brown University Programme in Medicine and Departments of Paediatrics

  4. 4

    Women and Infants’Hospital of Rhode Island

  5. 5

    Rhode Island Hospital Providence, Rhode Island 02902

  1. †

    See Acknowledgments

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

Haemoglobin AI, (Hb AIc), a glycohaemoglobin present in normal human blood, is elevated in glucose intolerant individuals. In non-pregnant diabetic subjects, a direct relationship has been established between per cent Hb AIc and blood and urinary glucose levels over weeks and months. In this study, Hb AI, level and mean random blood glucose concentration in the third trimester of pregnancy were found to correlate directly in 12 diabetic women without vascular disease (Pt0.001). In this same group of women, third trimester Hb AIc levels also correlated significantly with infant birth weight (P<O ·05) and birth weight adjusted for gestational age (P<O·Ol). Finally, third trimester mean blood glucose concentrations also correlated directly with birth weight (P t O ·05) and adjusted birth weight (P <0·001). In pregnancies complicated by diabetes, rigid glucose control has been recommended to achieve optimal fetal and maternaloutcomes. Hb AI, is a new tool with which to assess blood glucose control during diabetic pregnancy.

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