Mercy Maternity Hospital, 126 Clarendon Street, East Melbourne 3002, Australia.
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SEQUENTIAL CHANGES IN THE HUMAN RENIN-ANGIOTENSIN SYSTEM FOLLOWING DELIVERY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1978.tb15836.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 85, Issue 11, pages 821–827, November 1978
Additional Information
How to Cite
Pipkin, F. B., Oats, J. J. N. and Symonds, E. M. (1978), SEQUENTIAL CHANGES IN THE HUMAN RENIN-ANGIOTENSIN SYSTEM FOLLOWING DELIVERY. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 821–827. doi: 10.1111/j.1471-0528.1978.tb15836.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Plasma renin activity and concentration and angiotensin II concentration have been measured serially in six normotensive primigravidae and in four mildly hypertensive patients in the four hours immediately following normal delivery. In normotensive patients, both renin and angiotensin II levels fell sharply over the first two hours to levels within the non-pregnant range, with a subsequent rise to levels similar to those found in late pregnancy. Changes in the mildly hypertensive patients were smaller, and somewhat slower. It is suggested that the initial fall represents clearance of a renin of fetoplacental origin and that the subsequent rise may be a release from feedback suppression of renal renin synthesis.