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EFFECT OF INTRAVENOUS INFUSION OF BETASYMPATHOMIMETIC AGENTS ON PLASMA RENIN ACTIVITY DURING PREGNANCY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1978.tb15837.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 85, Issue 11, pages 828–831, November 1978
Additional Information
How to Cite
Lammintausta, R., Erkkola, R. and Katainen, P. (1978), EFFECT OF INTRAVENOUS INFUSION OF BETASYMPATHOMIMETIC AGENTS ON PLASMA RENIN ACTIVITY DURING PREGNANCY. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 828–831. doi: 10.1111/j.1471-0528.1978.tb15837.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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Summary
The plasma renin activity (PRA) was measured in 26 pregnant patients before and during ritodrine infusion (10 patients), during isoxsuprine infusion (12 patients), and during glucose infusion (4 control patients). All patients were in the third trimester of pregnancy, not in labour and not hypertensive. A low dose of ritodrine, a beta, adrenergic agent, caused a rise of PRA but no simultaneous rise in heart rate; this suggests that beta, activity is involved in renin release. Normal doses of ritodrine and isoxsuprine increased the maternal heart rate to 110 to 120 beats/minute and also doubled the PRA level. Two hours after the end of the ritodrine infusion the PRA level was still above that before the infusion. The results suggest high reserves of renin during pregnancy.