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FAILURE TO SUPPRESS ADRENAL FUNCTION IN CONGENITAL ADRENAL HYPERPLASIA (2 1 -HYDROXYLA SE DEFICIENCY) THREE CASE REPORTS
Article first published online: 31 AUG 2005
DOI: 10.1111/j.1471-0528.1978.tb15861.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 85, Issue 12, pages 965–969, December 1978
Additional Information
How to Cite
Beazley, J. M., Sells, R. A., Hipkin, L. J. .., Diver, M. J., Wade, A. P. and Davis, J. C. (1978), FAILURE TO SUPPRESS ADRENAL FUNCTION IN CONGENITAL ADRENAL HYPERPLASIA (2 1 -HYDROXYLA SE DEFICIENCY) THREE CASE REPORTS. BJOG: An International Journal of Obstetrics & Gynaecology, 85: 965–969. doi: 10.1111/j.1471-0528.1978.tb15861.x
Publication History
- Issue published online: 31 AUG 2005
- Article first published online: 31 AUG 2005
- Abstract
- References
- Cited By
Summary
Three patients, aged 14, 16, and 32 years respectively, with congenital adrenal hyperplasia (21 -hydroxylase deficiency) are described. Excessive adrenal activityand ACTH secretion could not be suppressed with doses of corticosteroids sufficient to cause iatrogenic Cushing's syndrome, even though part of the steroid dosage was administered in the late evening. The resistance to feed-back suppression was of the same order as that seen in Cushing's syndrome. Adrenalectomy was performed in the 16-year-old girl, and was followed by a menarche. Adrenalectomy was considered inadvisable in the other two patients.