Boston Hospital for Women, Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts02115, USA.
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ACTIVITY AND CHARACTERIZATION OF A LOW MOLECULAR FRACTION PRESENT IN HUMAN AMNIOTIC FLUID WITH BROAD SPECTRUM ANTIBACTERIAL ACTIVITY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1979.tb10572.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 86, Issue 2, pages 81–86, February 1979
Additional Information
How to Cite
Sachs, B. P. and Stern, C. M. (1979), ACTIVITY AND CHARACTERIZATION OF A LOW MOLECULAR FRACTION PRESENT IN HUMAN AMNIOTIC FLUID WITH BROAD SPECTRUM ANTIBACTERIAL ACTIVITY. BJOG: An International Journal of Obstetrics & Gynaecology, 86: 81–86. doi: 10.1111/j.1471-0528.1979.tb10572.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
The isolation of a low molecular weight fraction from amniotic fluid with broad spectrum antimicrobial activity is reported. This fraction consists of a family of peptides whose bactericidal activity is zinc dependent and can be inhibited by phosphate. Peptides are present in early gestation in low concentration increasing in amount from about 28 weeks gestation when antimicrobial activity becomes detectable in whole amniotic fluid. A simple bacteriological assay for this material is described. Its relation to the occurrence of perinatal infection is discussed.