Division of Perinatal Medicine, Clinical Research Centre, Watford Road, Harrow, HA1 3UJ, Middlesex.
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METABOLISM OF DIPHENYLHYDANTOIN (PHENYTOIN) DURING PREGNANCY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1979.tb10579.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 86, Issue 2, pages 125–132, February 1979
Additional Information
How to Cite
Landon, M. J. and Kirkley, M. (1979), METABOLISM OF DIPHENYLHYDANTOIN (PHENYTOIN) DURING PREGNANCY. BJOG: An International Journal of Obstetrics & Gynaecology, 86: 125–132. doi: 10.1111/j.1471-0528.1979.tb10579.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Plasma levels of diphenylhydantoin (DPH) and the 24 hour urinary excretion of both DPH and its major metabolite 5-(p-hydroxyphenyl)-phenylhydantoin (HPPH) were measured serially during pregnancy in a group of five unselected epileptic patients. Plasma DPH levels fell and on average were some 40 per cent lower at term than they had been in early pregnancy. With one exception, the patients were well controlled during pregnancy but two patients who regularly had plasma DPH levels below 10 μ/ml both suffered seizures in the puerperium. There was no convincing change in the excretion of either DPH or HPPH which together accounted for less than half the administered dose. Gestational length exceeded 41 weeks in 4 of the 5 patients studied but all were delivered of normal healthy infants, of average birthweight, with no congenital defects or clotting disorders.