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INHIBITION OF PROSTAGLANDIN-INDUCED UTERINE ACTIVITY BY NIFEDIPINE

  1. K.-E. Anderson,
  2. I. Ingemarsson,
  3. U. Ulmsten,
  4. L. Wingerup

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1979.tb10590.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 86, Issue 3, pages 175–179, March 1979

Additional Information

How to Cite

Anderson, K.-E., Ingemarsson, I., Ulmsten, U. and Wingerup, L. (1979), INHIBITION OF PROSTAGLANDIN-INDUCED UTERINE ACTIVITY BY NIFEDIPINE. BJOG: An International Journal of Obstetrics & Gynaecology, 86: 175–179. doi: 10.1111/j.1471-0528.1979.tb10590.x

Author Information

  1. Departments of Clinical Pharmacology and Obstetrics and Gynaecology University Hospital, Lund and Department of Obstetrics and Gynaecology Malmö General Hospital, University of Lund, Sweden

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

The effects of the calcium antagonist, nifedipine, on uterine activity induced by prostaglandins F2α (PGFZ2α) and E2 (PGE2) were studied in women undergoingtherapeutic midtrimester abortion, and in patients with a missed abortion in the 16th to 27th week of pregnancy. In the five subjects receiving intra-amniotic PGF2α (25 to 40 mg) for midtrimester abortion, nifedipine (30 mg orally) decreased uterine activity from a mean of 372 to 203 Montevideo Units. The effect on the intensity of the contractions was pronounced; frequency and basal tone were little affected. In patients with missed abortion, uterine contractions were induced by extra-amniotic application of PGE2 (0.5 to 1.5 mg) in a viscous gel. The activity was often more irregular than that in the women receiving intra-amniotic PGF2α. However, nifedipine (30 mg orally) had a marked inhibitory effect on the uterine contractions. It is concluded that nifedipine can be used for treatment of uterine hyperactivity induced by prostaglandins. Combined treatment with β2-adrenoceptor stimulants might be considered.

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