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THE RELATION BETWEEN PLASMA UNCONJUGATED OESTRIOLAND CYSTlNE AMINOPEPTIDASE CONCENTRATIONS ANDUTERINE CONTRACTIONS

  1. M. G. R. Hull Lecturer1,†,
  2. P. P. Monro Graduate Technician1,
  3. B. W. Ellis Registrar2

Article first published online: 23 AUG 2005

DOI: 10.1111/j.1471-0528.1979.tb10591.x

Issue

BJOG: An International Journal of Obstetrics & Gynaecology

BJOG: An International Journal of Obstetrics & Gynaecology

Volume 86, Issue 3, pages 180–185, March 1979

Additional Information

How to Cite

Hull, M. G. R., Monro, P. P. and Ellis, B. W. (1979), THE RELATION BETWEEN PLASMA UNCONJUGATED OESTRIOLAND CYSTlNE AMINOPEPTIDASE CONCENTRATIONS ANDUTERINE CONTRACTIONS. BJOG: An International Journal of Obstetrics & Gynaecology, 86: 180–185. doi: 10.1111/j.1471-0528.1979.tb10591.x

Author Information

  1. 1

    Department of Obstetrics and Gynaecology

  2. 2

    Surgical Unit St Mary's Hospital Medical School, London W.2

  1. †

    University Department of Obstetrics and Gynaecology, Bristol Maternity Hospital, Bristol BS2 8EG.

Publication History

  1. Issue published online: 23 AUG 2005
  2. Article first published online: 23 AUG 2005

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Summary

The relation between maternal plasma unconjugated oestriol (E3) concentrations and uterine activity was investigated by very frequent, carefully timed determinations of E, during synchronously recorded uterine contractions in six normal subjects. There was an initial rise (10 to 50 per cent above the mean) in E3 levels reaching a peak coincident with the contraction peak (range 20 seconds before to 15 seconds after) followed by a fall of similar magnitude below the mean reaching a nadir about 80 seconds (range 60 to 105 seconds) after the contraction peak. Although the pattern of E3 fluctuation was most marked in labour the overall degree of variation was no greater than at other times. Cystine aminopeptidase (CAP) concentrations in the same serum samples showed no significant correlation with uterine contractions. The reasons for, and practical applications of, the E3 results are discussed.

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