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THE POSSIBLE ROLE OF PROSTAGLANDINS IN THE SYSTEM IN THE NEWBORN HYPERFUNCTION OF THE RENIN-ANGIOTENSIN-ALDOSTERONE
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1979.tb10594.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 86, Issue 3, pages 205–209, March 1979
Additional Information
How to Cite
Sulyok, E., Németh, M., Tényi, I., Csaba, I. F., Thurzó, V. and Hadnagy, J. (1979), THE POSSIBLE ROLE OF PROSTAGLANDINS IN THE SYSTEM IN THE NEWBORN HYPERFUNCTION OF THE RENIN-ANGIOTENSIN-ALDOSTERONE. BJOG: An International Journal of Obstetrics & Gynaecology, 86: 205–209. doi: 10.1111/j.1471-0528.1979.tb10594.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
Plasma renin activity and plasma aldosterone concentration were measured by radioimmunoassay in eight newborn infants born vaginally to mothers on indomethacin treatment. Measurements were made in venous cord blood at birth and on the sixth day of life. The results were compared to those obtained in eight healthy control newborn infants of similar gestational age and birth weight. Maternal treatment with indomethacin was associated with a decrease of plasma renin activity (mean±SD) from 16.71±2.76 ng/ml/hour in the control group to 9.60±3.84 ng/ml/hour in the treated group. Plasma aldosterone concentration was lower in the cord blood of the treated group and a similar trend was demonstrated in the sixth day samples. It is suggested that the increased endogenous prostaglandin production during labour may be one of the factors responsible for the development of hyperactivity of renin-angiotensin-aldosterone system in the newborn.