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TESTOSTERONE PRODUCTION WITH HYDATIDIFORM MOLES IN VITRO AND IN VIVO STUDIES
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1979.tb10681.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 86, Issue 1, pages 37–40, January 1979
Additional Information
How to Cite
Chew, P. C. T., Goh, H. H. and Ratnam, S. S. (1979), TESTOSTERONE PRODUCTION WITH HYDATIDIFORM MOLES IN VITRO AND IN VIVO STUDIES. BJOG: An International Journal of Obstetrics & Gynaecology, 86: 37–40. doi: 10.1111/j.1471-0528.1979.tb10681.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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- Cited By
Summary
Fresh molar tissues obtained from seven patients were incubated in vitro with dehydroepiandrosterone and androstenedione. The testosterone concentration in molar tissue ranged from 5.4 ng/g wet weight to 43.8 ng/g wet weight. Both precursors were readily converted to testosterone indicating that 17-hydroxysteroid dehydrogenase and 3β-hydroxysteroid dehydrogenase are present in molar trophoblast. A 50 mg dose of dehydroepiandrosterone was infused into patients with hydatidiform mole before and after uterine evacuation. There was a testosterone peak preceding an oestrogen rise which disappeared after uterine evacuation. It is suggested that the elevated testosterone level in molar pregnancy is mainly due to the conversion of dehydroepiandrosterone in the molar trophoblast.