Senior Registrar in Obstetrics and Gynaecology, Southampton General Hospital.
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AN ANALYSIS OF THE INFLUENCES OF MATERNAL AGE, GESTATIONAL AGE, CONTRACEPTIVE METHOD, AND THE MODE OF PRIMARY TREATMENT OF PATIENTS WITH HYDATIDIFORM MOLES ON THE INCIDENCE OF SUBSEQUENT CHEMOTHERAPY
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1979.tb10694.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 86, Issue 10, pages 782–792, October 1979
Additional Information
How to Cite
Stone, M. and Bagshawe, K. D. (1979), AN ANALYSIS OF THE INFLUENCES OF MATERNAL AGE, GESTATIONAL AGE, CONTRACEPTIVE METHOD, AND THE MODE OF PRIMARY TREATMENT OF PATIENTS WITH HYDATIDIFORM MOLES ON THE INCIDENCE OF SUBSEQUENT CHEMOTHERAPY. BJOG: An International Journal of Obstetrics & Gynaecology, 86: 782–792. doi: 10.1111/j.1471-0528.1979.tb10694.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
- References
- Cited By
Summary
In relation to the total number of births in the United Kingdom there was an excess of hydatidiform moles arising in women over 34 years of age and possibly also under 15. The incidence of trophoblastic tumour requiring chemotherapy after hydatidiform mole was greatest in the 30 to 34 year age group and it was also high in the 20 to 24 year age group. This distribution appears to be influenced by the morphology of the moles, the mode of their removal and the use of oestrogens and progestogens in the post-evacuation period. The need for chemotherapy for trophoblastic tumour after evacuation of a hydatidiform mole was found to be two- to three-fold greater in patients who had undergone a medical induction, hysterectomy or hysterotomy compared with those whose hydatidiform moles had been evacuated by vacuum or surgical curettage, or who had aborted spontaneously. The increased risk of chemotherapy was most marked in the earlier weeks of gestation.