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CHLORMETHIAZOLE TREATMENT AND BREAST FEEDING
Article first published online: 23 AUG 2005
DOI: 10.1111/j.1471-0528.1979.tb10695.x
Issue
1471-0528/asset/cover.gif?v=1&s=b4e1d96c46e18c61210d584b63c13ee375cf562b "BJOG: An International Journal of Obstetrics & Gynaecology")
BJOG: An International Journal of Obstetrics & Gynaecology
Volume 86, Issue 10, pages 793–798, October 1979
Additional Information
How to Cite
Tunstall, M. E., Campbell, D. M., Dawson, B. M. and Jostell, K.-G. (1979), CHLORMETHIAZOLE TREATMENT AND BREAST FEEDING. BJOG: An International Journal of Obstetrics & Gynaecology, 86: 793–798. doi: 10.1111/j.1471-0528.1979.tb10695.x
Publication History
- Issue published online: 23 AUG 2005
- Article first published online: 23 AUG 2005
- Abstract
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- Cited By
Summary
Four mothers receiving chlormethiazole for pre-eclampsia and their babies were the subjects of the investigation. Blood samples at delivery and blood and breast milk samples in the postpartum period were analysed for chlormethiazole. Concentrations ranged from 1·340 to 1·640 ug/g of sample in umbilical artery blood at birth, and fell to 0·010 to 0·153 ug/g in capillary blood 20 to 26 hours later. After the start of breast feeding, chlormethiazole in the babies was detectable in only 3 out of 27 serial blood samples and was 0·018, 0·009 and 0·006 μg/g. The highest calculated amount of chlormethiazole ingested at a breast feed was 37.2 ug. It is suggested that breast feeding should not be delayed solely on account of chlormethiazole therapy.